Development of multiepitope subunit protein vaccines against Toxoplasma gondii using an immunoinformatics approach
نویسندگان
چکیده
منابع مشابه
Veterinary vaccines against Toxoplasma gondii.
Toxoplasma gondii has a very wide intermediate host range and is thought to be able to infect all warm blooded animals. The parasite causes a spectrum of different diseases and clinical symptoms within the intermediate hosts and following infection most animals develop adaptive humoral and cell-mediated immune responses. The development of protective immunity to T. gondii following natural infe...
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Development of vaccines against Toxoplasma gondii infection in humans is of high priority, given the high burden of disease in some areas of the world like South America, and the lack of effective drugs with few adverse effects. Rodent models have been used in research on vaccines against T. gondii over the past decades. However, regardless of the vaccine construct, the vaccines have not been a...
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Background & Aims: Toxoplasma gondii is an obligate, intracellular parasite, which is widely spread in the world. The parasite is able to infect all warm-blooded hosts including humans and farm animals. The infection in humans often occurs after the ingestion of raw or undercooked meat containing tissue cysts. Several methods have been applied to detect this parasite in contaminated foods. Reco...
متن کاملAn evaluation of a recombinant multiepitope based antigen for detection of Toxoplasma gondii specific antibodies
BACKGROUND The inefficiency of the current tachyzoite antigen-based serological assays for the serodiagnosis of Toxoplasma gondii infection mandates the need for acquirement of reliable and standard diagnostic reagents. Recently, epitope-based antigens have emerged as an alternative diagnostic marker for the achievement of highly sensitive and specific capture antigens. In this study, the diagn...
متن کاملEvaluation of a recombinant multiepitope peptide for serodiagnosis of Toxoplasma gondii infection.
Detection of Toxoplasma gondii infection with sensitive and specific methods is a key step in the prevention and treatment of toxoplasmosis. Among the available diagnostic tests, serology is commonly used. Although serological tests give satisfactory results, the production of reliable reagents remains laborious and expensive. There is therefore a real need to acquire specific and effective rec...
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ژورنال
عنوان ژورنال: NAR Genomics and Bioinformatics
سال: 2020
ISSN: 2631-9268
DOI: 10.1093/nargab/lqaa048